Environmental Engineering for Stopping Viruses Pandemics

Engineering responses to pandemics

Focusing on pandemic influenza, this chapter approaches the planning for and response to such a major worldwide health event as a complex engineering systems problem. Action-oriented analysis of pandemics requires a broad inclusion of academic disciplines since no one domain can cover a significant fraction of the problem. Numerous research papers and action plans have treated pandemics as pure...

Environmental Engineering for Coastal Protection

Approved for public release; distribution is unlimited. 1. Purpose. The purpose of this manual is to provide guidance in enviromental engineering for coastal shore protection projects. 2. Applicability. This manual applies to all field operating activities that have responsibility for environmental impact studies related to coastal shore protection projects. 3. Discussion. This manual summarize...

Stockpiling Ventilators for Influenza Pandemics

Stockpiling Ventilators for Influenza Pandemics

In preparing for influenza pandemics, public health agencies stockpile critical medical resources. Determining appropriate quantities and locations for such resources can be challenging, given the considerable uncertainty in the timing and severity of future pandemics. We introduce a method for optimizing stockpiles of mechanical ventilators, which are critical for treating hospitalized influen...

Engineering Viruses to Fight Cancer

With EMA approval in December 2015, and US FDA approval in October 2015 of an oncolytic herpesvirus for the treatment of nonresectable melanoma, we now have a novel class of anticancer agents to add to our ever-promising arsenal of cancer (immuno-) therapeutics. Talimogen laherparapvec (T-VEC) therapy involves direct, intratumoral injection of a herpes simplex type 1 (HSV-1) virus which has bee...